Clonidine and insulin tests for growth hormone deficiency.

High and low dose clonidine tests for the diagnosis of growth hormone deficiency.

The growth hormone (GH) response to three provocative stimuli was assessed in 15 short normal children (ISS) and 5 children with GH deficiency (GHD). The pharmacologic agents used were insulin 0.1 unit/kg IV (IHT), oral clonidine 0.15 mg/m2 (HDCT) and 25 micrograms irrespective of age and weight (LDCT). Blood glucose and GH were measured at 0, 30, 60, 75, 90 and 120 minutes; and BP and serum co...

Diagnostic Value of Provocative Test by Insulin Combined with Clonidine for Growth Hormone Deficiency in Children

OBJECTIVE To evaluate the diagnostic value of provocative test by insulin combined with clonidine for growth hormone deficiency (GHD) during childhood. METHODS Eighty children underwent a provocative test with insulin(0.075U/Kg, intravenous) combined with clonidine (4μg/kg, orally). Among them, 40 children underwent clonidine provocative test, 40 children underwent insulin tolerance test (ITT...

Clonidine is a better test for growth hormone deficiency than insulin hypoglycaemia.

The oral clonidine test was compared with the standard intravenous insulin hypoglycaemia test in 41 children and adolescents with short stature. In those without growth hormone deficiency clonidine provoked a significantly higher mean plasma growth hormone response and gave fewer false subnormal responses (apparent growth hormone deficiency) than insulin. Children with psychosocial deprivation ...

Diagnosis of Growth Hormone Deficiency and Growth Hormone Stimulation Tests

Insulin like growth factors and growth hormone deficiency.

polypeptides that act as endocrine mediators of growth hormone (GH)-induced actions. They also function in a paracrine and autocrine manner to regulate cell growth, differentiation, apoptosis and transformation. The IGF system is a complex network comprised of two growth factors (IGF-I and -II), cell surface receptors (IGF-IR and -IIR), high affinity binding proteins (IGFBP), IGFBP proteases as...